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Vogue's Top 25 in Beauty, Health, and Fitness: Previews, predictions, prescriptions, and new obsessions for 2007

It was sheer desperation that drove Lisa Hoffman to develop her breakthrough skin care line. Years of living on location in Paris, London, and Morocco with her Academy-Award winning husband (that would be Dustin) and their children "meant my life revolved around packing and unpacking my toiletries," she says. That is, until she dreamed up the idea of a complete beauty regimen based on single-dose ampoules, designed to hold the perfect amount of the perfect treatment. This month, frequent fliers can flock to Bergdorf Goodman, where her self-titled anti-aging cleansers, creams, serums, and lip treatments—loaded with ingredients like the line-fighting Matrixyl 3000 and BVOSC, a highly stable form of Vitamin C—are offered in airtight, numbered plastic vials ("so there's no wondering whether you should put your cream or serum on first," she says). Up next on the drawing board: travel ready ampoules for the bath and shower, the at-home (or hotel room) facial, and fragrance.